The use of cannabis, prescription drugs, and other drugs are increasingly prominent on roadways in the United States, where 25.3 percent of the nation’s 38,824 fatalities in 2020 were related to drug-involved driving. Driving can be impaired by a variety of legal and illegal drugs, substances, and medications. The effect of specific drugs on behavior and driving skills vary considerably depending on how they act in the brain and are metabolized. They can slow reaction time, decrease coordination, increase aggressive and reckless driving, impair cognitive function, or cause drowsiness. All of...